出版日期：2026-04-01 00:00:00

著者：J. Mohanraj; M. Valliammai; Lung-Jieh Yang; Gulothungan G; N. Ayyanar; Jeyanthi P

著錄名稱、卷期、頁數：IEEE Sensors Letters 10(4), p.1500904

摘要：In this letter, we propose a highly sensitive evanescent field-based side polished fiber (SPF) biosensor nanocoated with tungsten disulfide (WS2) quantum dots (QDs) for the label-free detection of Parkinson's disease (PD). Alpha-synuclein (α-syn) is identified as a key biomarker for the early and rapid diagnosis of PD. The sensing mechanism relies on surface plasmon resonance (SPR)-based interaction between the evanescent field in the anti-α-syn antibodies immobilized on the (WS2) QDs and SPF region. The proposed biosensor demonstrates a sensitivity of 85% with a limit of detection around 0.517 fg/mL. A maximum SPR wavelength shift of 97.62 nm was observed at an α-syn concentration of 105 fg/mL. Further, the proposed biosensor exhibits an excellent selectivity toward α-syn compared to potential interfering proteins, such as amyloid-beta (Aβ42) and bovine serum albumin. Thus, the proposed WS2 QDs nano-coated SPF biosensor is a promising platform for point-of-care diagnostics and preclinical assessment of PD.

語言：en_US

ISSN：2475-1472

期刊性質：國外

收錄於：SCI Scopus

通訊作者：J. Mohanraj

審稿制度：是

國別：USA

出版型式：電子版